✅ Medically reviewed | Updated July 2026

Most men researching this treatment hit the same wall: glossy marketing pages that promise transformation but skip the actual science. You deserve more than vague claims and a “call for pricing” button. This guide breaks down exactly what happens inside your body during treatment, what peer-reviewed research actually found, and every practical detail you need before booking a consultation. No fluff. No guesswork. Just the evidence, explained clearly.

What Is the P-Shot?

The P Shot, also called the Priapus Shot, uses your own blood to trigger tissue repair. Doctors draw a small blood sample, spin it in a centrifuge, and extract platelet-rich plasma (PRP). They then inject this plasma directly into penile tissue. The name comes from Priapus, the Greek god of fertility, which explains the treatment’s original branding.

The entire concept rests on a simple idea: your platelets already contain the tools your body needs to heal itself. Doctors simply concentrate those tools and deliver them precisely where you need them most.

Why Doctors Use PRP for This Purpose

Physicians have used PRP in orthopaedics and wound care for decades. Surgeons apply it to slow-healing tendons. Dermatologists use it for skin rejuvenation. Researchers eventually asked whether the same regenerative mechanism could help erectile tissue, and clinical interest in Priapus shot treatment grew from there.

How the P-Shot Works Inside Your Body

Understanding the mechanism matters more than most clinics admit. When doctors inject PRP into penile tissue, four biological processes activate.

Angiogenesis: New Blood Vessel Formation

Growth factors in PRP stimulate your body to build new capillary networks. More blood vessels mean more oxygenated blood reaching the tissue that drives erection quality. This is the vascular foundation behind most reported improvements.

Collagen and Elastin Production

PRP encourages collagen and elastin growth inside the corpora cavernosa, the spongy chambers that fill with blood during an erection. Stronger tissue structure supports firmness and may improve tissue quality over time.

Nerve Fibre Renewal

For men who have lost sensitivity through age, surgery, or medication, this step often produces the most noticeable change. PRP growth factors support nerve regeneration, which can restore responsiveness that felt permanently reduced.

Anti-Inflammatory Action

Patients with Peyronie’s disease or lichen sclerosus benefit from PRP’s anti-inflammatory properties. This action may reduce plaque formation, soften scar tissue, and ease discomfort associated with these conditions.

The Key Growth Factors Behind the Results

PRP contains five primary growth factors that drive the regenerative process:

• PDGF (Platelet-Derived Growth Factor) – stimulates cell growth
• VEGF (Vascular Endothelial Growth Factor) – drives new blood vessel formation
• TGF-β (Transforming Growth Factor) – supports tissue repair
• EGF (Epidermal Growth Factor) – promotes cell regeneration
• FGF (Fibroblast Growth Factor) – encourages collagen production

These proteins do not come from a lab. They come from your own blood, concentrated to a level your body cannot achieve naturally on its own.

What Does the Clinical Research Actually Show?

Here is where most competitor articles fall silent, and it is the most important section for anyone genuinely evaluating this treatment.

A randomised, double-blind, placebo-controlled trial published in the Journal of Sexual Medicine in 2021 examined PRP injections for erectile dysfunction. Researchers Poulios and colleagues found that patients receiving PRP showed a clinically significant improvement in erectile function scores at the six-month mark compared with the placebo group (Poulios et al., 2021, Journal of Sexual Medicine, 18(5), 926–935).

This matters because double-blind, placebo-controlled trials represent the gold standard in medical research. Neither patients nor assessors knew who received the real treatment, which removes bias from the results.

What This Research Does Not Claim

Honest reporting requires honest limitations. PRP therapy for male sexual health remains a developing field. Results vary between patients, and researchers continue building the evidence base. Doctors should never present early clinical interest as guaranteed outcomes, and any clinic that promises universal results is overstating what the science currently supports.

Who Responds Best to the P-Shot?

Clinical experience suggests certain groups see more consistent results than others.

Strong Candidates

• Men with mild to moderate erectile dysfunction, particularly where reduced blood flow plays a role
• Men who have not responded well to PDE5 inhibitors like Viagra or Cialis
• Patients with Peyronie’s disease during the active phase of the condition
• Men experiencing gradually reduced sensitivity linked to age or nerve changes
• Patients managing lichen sclerosus symptoms, where evidence is still developing but early results look encouraging

Who Should Avoid This Treatment

• Anyone with an active genital infection or sexually transmitted infection
• Patients with bleeding disorders or platelet dysfunction
• Men currently on anticoagulant therapy, unless a doctor clears this beforehand
• Patients undergoing active cancer treatment in the pelvic region
• Anyone with a known allergy to local anaesthetics

A proper consultation always precedes treatment, and a responsible doctor will tell you honestly if you are not a suitable candidate.

What Happens During Your Appointment

Doctors perform the entire procedure as a straightforward outpatient visit lasting roughly 30 to 45 minutes. Here is the full sequence.

Step 1: Preparation and Numbing (10 Minutes)

Staff settle you into a private treatment room and apply a topical numbing cream. If you prefer stronger comfort, doctors can offer a penile nerve block instead, so mention this preference when booking.

Step 2: Blood Collection (5 Minutes)

A nurse draws a small blood sample from your arm using a sterile tube. The amount resembles a routine blood test, and this remains the only needle placement away from the treatment area.

Step 3: PRP Processing (15 Minutes)

Technicians place your blood sample into a medical-grade centrifuge. A dual-spin protocol concentrates platelets to a higher level than standard single-spin processing, which directly affects treatment quality.

Step 4: Extraction (5 Minutes)

Once processing finishes, doctors draw the concentrated PRP into syringes and calibrate the volume based on your individual assessment.

Step 5: Targeted Injection (10 Minutes)

Doctors administer the PRP using ultra-fine needles. Most patients describe the sensation as mild pressure rather than genuine pain, largely because the numbing cream has already taken effect. The precise penile injection typically involves four to five placement points, depending on your specific protocol.

Step 6: Aftercare Guidance

Before you leave, your doctor walks through aftercare instructions directly. Some clinics also provide a medical-grade vacuum device for home use during early healing.

Recovery Timeline: What to Expect Week by Week

Growth factors do not work overnight, and understanding the timeline prevents unrealistic expectations.

Days 1 to 2

Minor swelling or localised sensitivity may occur, which resolves naturally within 24 to 48 hours. Most patients notice no visible signs that treatment took place.

Days 4 to 5

Doctors typically advise abstaining from sexual activity during this window to let treated tissue settle properly. After this point, you can resume normal activity.

Week 4

Many patients report their first noticeable changes here. Sensitivity often increases, and some men notice stronger morning erections as the angiogenic process actively progresses.

Weeks 8 to 12

This period usually produces the most significant improvements. Patients commonly report better erection quality, firmness, and confidence. Men with Peyronie’s disease may notice reduced curvature or discomfort during this window.

12 Months and Beyond

Results can persist for 12 months or longer, though this varies by individual. Many men opt for an annual maintenance session to sustain their outcomes.

How Much Does the P-Shot Cost in London?

Transparent pricing matters, and vague “price on request” listings frustrate patients trying to plan ahead. Priapus shot price structures should always be published clearly before you book.

At Dr SNA Clinic in London, treatment starts from £1,250 for a standard single session using the dual-spin centrifuge protocol. This price includes your initial consultation, PRP processing, topical numbing or nerve block, the injection procedure performed personally by your doctor, and both a six-week and twelve-week follow-up consultation.

An enhanced package combining the P Shot with low-intensity shockwave therapy is available from £1,350, which is recommended when vascular factors significantly contribute to erectile dysfunction. 0% finance is available for patients who prefer to spread the cost over several months.

How the P-Shot Compares to Other Treatments

Treatment	Typical Cost	Type	Results Timeline	Downtime	How Long Results Last
P-Shot PRP	From £1,250	Autologous	3–6 weeks	None	12+ months
P-Shot + Shockwave	From £1,350	Autologous	3–6 weeks	None	12+ months
PDE5 Medication	Ongoing cost	Synthetic	Immediate	None	4–6 hours
Shockwave Alone	£500 per session	Mechanical	2–3 weeks	None	Up to 2 years
Penile Implants	£8,000–£15,000	Surgical	Immediate	4–6 weeks	10+ years

Unlike PDE5 medications, the P Shot addresses underlying tissue physiology rather than temporarily masking symptoms. Unlike surgical implants, it involves no incisions and no lengthy recovery.

Booking Your Appointment in London

If you are searching for a P shot London clinic with transparent pricing and a doctor who personally performs every step, appointments run from 10:00 to 18:00 UK time. The London clinic sits at 48 Wimpole Street, Marylebone, London W1G 8SF, and treatment is delivered at a CQC-regulated facility.

You can reach the clinic directly by phone at +44 7955 836986 to arrange your consultation or ask questions about male enlargement injections cost UK before committing to anything.

Frequently Asked Questions

Does the P-Shot Hurt?

Most patients describe mild pressure rather than pain, thanks to topical numbing cream applied before injection. A nerve block option exists for men with a lower pain threshold.

How Long Do Results Last?

Results typically last 12 months or longer on average, though individual experiences vary depending on age, circulation, and lifestyle factors.

Can the P-Shot Replace Viagra or Cialis?

The P-Shot works differently than PDE5 medications. Rather than producing an immediate, temporary effect, it targets underlying blood flow and tissue health. Some men use it as a drug-free alternative, particularly if they cannot tolerate oral medications.

Is There Real Clinical Evidence for the P-Shot?

Yes. A 2021 randomised, double-blind, placebo-controlled trial published in the Journal of Sexual Medicine found clinically significant improvement in erectile function scores at six months. The field continues developing, and results vary between patients.

How Many Sessions Will I Need?

Most patients start with a single session, followed by scheduled follow-ups at six and twelve weeks to assess progress. Some men choose an annual maintenance session afterward.

Is the P-Shot Suitable for Everyone?

No. Men with bleeding disorders, active infections, or those undergoing active pelvic cancer treatment are generally not suitable candidates. A consultation determines individual suitability.

For a visual walkthrough of the entire procedure, this explainer video covers the injection process and patient experience in detail.

Final Thought

The P Shot is not magic, and no responsible doctor will tell you otherwise. It is a biologically grounded treatment that uses your own regenerative material to support blood flow, nerve function, and tissue repair. The clinical evidence, while still growing, shows genuine promise for men with the right underlying condition. The most valuable next step is not another article. It is a direct conversation with a qualified doctor who can assess your specific situation honestly and tell you exactly what to expect.

Related Reading From Dr SNA Clinic

• P-Shot London — Full Treatment Overview and Pricing
• Is the P-Shot Worth Getting? An Honest Answer
• P-Shot for Erectile Dysfunction: What the Evidence Says
• P-Shot for Peyronie’s Disease: What Early Research Shows
• P-Shot for Lichen Sclerosus: What Early Research Shows
• Can the P-Shot Help With Low Libido?
• Erectile Dysfunction Treatment UK: Every Option Explained Honestly
• P-Shot Side Effects: What Are the Risks and How Common Are They?

Dr Syed Nadeem Abbas, MBBS, MRCSEd, MSc Aesthetic Plastic Surgery (Distinction) Medical Director, Dr SNA Clinic 48 Wimpole Street, Marylebone, London W1G 8SF GMC Registered | CQC Regulated | Monday to Saturday 10:00–18:00 +44 7955 836986 | info@drsnaclinic.com